Ultra-LEAF™ Purified anti-human CD117 (c-kit) Antibody, CD117, W18195E,BioLegend,380203
Clone W18195E can complete block binding of clones H18022H and W18195D on target cells.Clone W18195E does not affect binding of clones 104D2, W18195C or S18022G on target cells.Clone W18195E can block ligand binding on c-kit.
Host
Rat
Reactivity
Human
Application
FC - Quality testedBlock - Verified
Platform ID
BAB019246373
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NameUltra-LEAF™ Purified anti-human CD117 (c-kit) Antibody, CD117, W18195E
Cat. No.380203
HostRat
RRIDAB_2924570 (BioLegend Cat. No. 380203)
IsotypeRat IgG2a, λ
ReactivityHuman
ApplicationFC - Quality testedBlock - Verified
ClonalityMonoclonal
Clone NumberW18195E
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCD117
ImmunogenHuman CD117 transfectant
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only
Scientific Background
CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML). CD117 binding of c-Kit ligand induces phosphorylation of CD117 and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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