Ultra-LEAF™ Purified anti-human CD352 (NTB-A) Antibody, CD352, NT-7,BioLegend,317212

Additional reported applications (for the relevant formats) include: stimulation of NTB-A in a redirected lysis assay and blocking of NTB-A function3. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 317211 & 317212). Co-stimulation of cells with CD3 antibodies and clone NT-7 has been shown to induce activation rather than blocking function of these cells3.

Host

Mouse

Reactivity

Human

Application

FC -Quality testedBlock, Stim -Reported in the literature, not verified in house

Platform ID

BAB010761712

BioLegend

Headquarters

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BioLegend

Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameUltra-LEAF™ Purified anti-human CD352 (NTB-A) Antibody, CD352, NT-7
Cat. No.317212
HostMouse
RRIDAB_2860836 (BioLegend Cat. No. 317211)AB_2860837 (BioLegend Cat. No. 317212)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC -Quality testedBlock, Stim -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberNT-7
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCD352
ImmunogenRecombinant extracellular domain of NTB-A
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

NTBA (NK-, T-, and B-cell Antigen) is a 60 kD type I transmembrane glycoprotein. It is a member of Ig superfamily belonging to CD2/CD150 subfamily, also known as SLAMF6 (SLAM family member 6), LY108, TCOM, or SF2000. This antigen is expressed on NK cells, T cells (upregulated upon activation), and B cells. NTBA is its own ligand. The homophilic interaction of NTBA is involved in the induction of NK cytotoxicity, CD28 independent T cell costimulation, triggering Th1 cytokines production, and regulation of B cell tolerance. It may play a role in the regulation of autoimmune diseases.

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