Ultra-LEAF™ Purified anti-human CD357 (GITR) Antibody, CD357, W21071E,BioLegend,624753

NFRSF18 is a type I transmembrane protein that was initially identified from dexamethasone-treated murine T cell hybridoma cells, and was designated GITR (for glucocorticoid-induced TNFR family-related gene). The human TNFRSF18 has 56% amino acid sequence identity to the mouse receptor. The human and mouse receptors contain three cysteine rich domains (CRD) in their extracellular region. TNFRSF18 expression is up-regulated in human peripheral mononuclear cells after stimulation with anti-CD3/CD28 monoclonal antibodies. TNFRSF18 interacts with TRAF1 (TNF receptor-associated factor 1), TRAF2, and TRAF3, and induces nuclear factor NFkB activation via TRAF2. TNFRSF18 is a key player in the differentiation of thymic Tregs (tTregs), and expansion of both tTregs and peripheral Tregs (pTregs). Human regulatory T cells (Tregs) constitutively expresses TNFRSF18. TNFRSF18 and its ligand are involved in the pathogenesis of autoimmune disease.  Soluble forms for TNFRSF18 and TNFSF18 were detected in the serum of patients with primary Sjögren's syndrome, and those levels correlated with disease severity. Other autoimmune and allergic diseases have been associated to TNFRSF18 /TNFSF18 interaction as demonstrated in disease models of gastritis, thyroiditis, experimental autoimmune encephalomyelitis, and allergic airway inflammation.