Ultra-LEAF™ Purified anti-human CXCL11 (ITAC) Antibody, CXCL11, A15129H,BioLegend,945403

Host

Mouse

Reactivity

Human

Application

Neut - Quality tested

Platform ID

BAB609475571

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameUltra-LEAF™ Purified anti-human CXCL11 (ITAC) Antibody, CXCL11, A15129H
Cat. No.945403
HostMouse
RRIDAB_2892512 (BioLegend Cat. No. 945403)AB_2892512 (BioLegend Cat. No. 945404)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationNeut - Quality tested
ClonalityMonoclonal
Clone NumberA15129H
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCXCL11
ImmunogenRecombinant human CXCL11
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CXCL11 is a CXC chemokine lacking the ELR (Glutamate-Leucine-Arginine) tripeptide motif, which is functionally and structurally related to CXCL9 and CXCL10. CXCL11, together with CXCL9 and CXCL10, specifically binds to the G protein-coupled receptor CXCR3 and is involved in chemotaxis of immune cells and angiogenesis. CXCL11 expression is upregulated in response to interferons (IFNs). Expression of both CXCR3 and CXCL11 by the Th1-associated cytokine IFN-γ creates an amplification loop of cell-mediated immune response between Th1 cells. CXCR7 has been identified as an alternate receptor for CXCL11 and is involved in growth, survival, and adhesion of tumor cells. CXCL11 induces calcium release in activated T-cells and may play an important role in CNS diseases which involve T-cell recruitment.

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