Ultra-LEAF Purified anti-mouse CD11a Antibody anti-CD11a - M17/4,BioLegend,101117
The M17/4 antibody can block CD11a-mediated cellular adhesion. Additional reported applications of this antibody (for the relevant formats) include: immunoprecipitation1,2,in vitroblocking of cell-cell adhesion1,2and FOXP3 expression5, and immunohistochemical staining of acetone-fixed frozen sections3. The M17/4 antibody does not block the binding of 2D7 antibody (Cat. No. 101002) to CD11a. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 101110). Forin vivostudies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 101118) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).
Host
Rat
Reactivity
Mouse
Application
FC -Quality tested
Platform ID
BAB998067808
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NameUltra-LEAF Purified anti-mouse CD11a Antibody anti-CD11a - M17/4
Cat. No.101117
HostRat
RRIDAB_2819777 (BioLegend Cat. No. 101117)AB_2561478 (BioLegend Cat. No. 101118)AB_2819778 (BioLegend Cat. No. 101127)AB_2819779 (BioLegend Cat. No. 101128)AB_2819780 (BioLegend Cat. No. 101129)AB_2832270 (BioLegend Cat. No. 101130)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone NumberM17/4
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCD11a
ImmunogenC57BL/6 mouse splenic secondary cytotoxic T cells
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only
Scientific Background
CD11a is a 180 kD glycoprotein, also known as αLintegrin, LFA-1 α, Ly-15, or Ly-21. It is a member of the integrin family, primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes. In association with CD18, the CD11a/CD18 complex forms LFA-1. CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50).
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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