Ultra-LEAF™ Purified anti-mouse CD183 CXCR3 Antibody anti-CD183 - CXCR3-173,BioLegend,126538

Clone CXCR3-173 does not work for Western blotting.7Forin vivostudies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 126526) with endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered.

Host

Armenian Hamster

Reactivity

Mouse

Application

FC - Quality testedBlock - Reported in the literature, not verified in house

Platform ID

BAB466932760

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Contact

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Product Specifications
Scientific Background

Specifications

NameUltra-LEAF™ Purified anti-mouse CD183 CXCR3 Antibody anti-CD183 - CXCR3-173
Cat. No.126538
HostArmenian Hamster
RRIDAB_2832456 (BioLegend Cat. No. 126554)AB_11147756 (BioLegend Cat. No. 126526)AB_2571999 (BioLegend Cat. No. 126537)AB_2572000 (BioLegend Cat. No. 126538)AB_2832455 (BioLegend Cat. No. 126547)AB_2832456 (BioLegend Cat. No. 126548)
IsotypeArmenian Hamster IgG
ReactivityMouse
ApplicationFC - Quality testedBlock - Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberCXCR3-173
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCD183
ImmunogenMouse N-terminus of CXCR3
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.

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