Ultra-LEAF™ Purified anti-mouse CD278 (ICOS) Antibody, CD278, 7E.17G9,BioLegend,117418

Additional reported applications (for the relevant formats) include: blocking of ligand binding. The LEAF™ format is suggested for blocking studies.

Host

Rat

Reactivity

Mouse

Application

FC -Quality testedBlock -Reported in the literature, not verified in house

Platform ID

BAB009573547

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NameUltra-LEAF™ Purified anti-mouse CD278 (ICOS) Antibody, CD278, 7E.17G9
Cat. No.117418
HostRat
RRIDAB_2832411 (BioLegend Cat. No. 117413)AB_2832412 (BioLegend Cat. No. 117414)AB_2832413 (BioLegend Cat. No. 117415)AB_2832414 (BioLegend Cat. No. 117416)AB_2832415 (BioLegend Cat. No. 117417)AB_2832416 (BioLegend Cat. No. 117418)
IsotypeRat IgG2b, κ
ReactivityMouse
ApplicationFC -Quality testedBlock -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone Number7E.17G9
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCD278
ImmunogenMouse ICOS cDNA and ICOS hexahistidine fusion protein
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

The 7E.17G9 antibody reacts with the 47-57 kD ICOS protein, also known as inducible costimulatory molecule, and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.

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