Ultra-LEAF™ Purified anti-mouse CD6 Antibody, CD6, W20225B,BioLegend,167603

Clone W20225B can partially block the binding of clone OX-129 on target cells. Binding of W20225B on target cells can be enhanced by clone OX-129.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB647857139

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameUltra-LEAF™ Purified anti-mouse CD6 Antibody, CD6, W20225B
Cat. No.167603
HostRat
RRIDAB_3683198 (BioLegend Cat. No. 167603)AB_3683198 (BioLegend Cat. No. 167604)
IsotypeRat IgG2b, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberW20225B
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCD6
ImmunogenMouse CD6 transfected cells
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CD6 is a 100 kD monomeric glycoprotein found on the surface of T cells and is part of the scavenger receptor cysteine-rich (SRCR) superfamily. In mice, it is expressed on thymocytes, splenic T cells, and neurons, but not on splenic B cells. CD6 has a long cytoplasmic tail containing two proline-rich domains that bind to SH3 domain-containing proteins. Its interaction with its ligand, CD166 (ALCAM), acts as a costimulatory signal via SLP-76. CD6-mediated signaling plays a role in thymocyte survival and functional avidity in both mice and humans.

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