Ultra-LEAF™ Purified anti-mouse CXCL11 (ITAC) Antibody, CXCL11, A16031D,BioLegend,942703

Host

Rat

Reactivity

Mouse

Application

Neut - Quality tested

Platform ID

BAB735437609

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NameUltra-LEAF™ Purified anti-mouse CXCL11 (ITAC) Antibody, CXCL11, A16031D
Cat. No.942703
HostRat
RRIDAB_2892506 (BioLegend Cat. No. 942703)AB_2892506 (BioLegend Cat. No. 942704)
IsotypeRat IgG2a, λ
ReactivityMouse
ApplicationNeut - Quality tested
ClonalityMonoclonal
Clone NumberA16031D
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCXCL11
ImmunogenRecombinant mouse CXCL11
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CXCL11 is a CXC chemokine lacking the ELR (Glutamate-Leucine-Arginine) tripeptide motif, which is functionally and structurally related to CXCL9 and CXCL10. CXCL11, together with CXCL9 and CXCL10, specifically binds to the G protein-coupled receptor CXCR3 and is involved in chemotaxis of immune cells and angiogenesis. CXCL11 expression is upregulated in response to interferons (IFNs). Expression of both CXCR3 and CXCL11 by the Th1-associated cytokine IFN-γ creates an amplification loop of cell-mediated immune response between Th1 cells. CXCR7 has been identified as an alternate receptor for CXCL11 and is involved in growth, survival, and adhesion of tumor cells. CXCL11 induces calcium release in activated T-cells and may play an important role in CNS diseases which involve T-cell recruitment.

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