Ultra-LEAF™ Purified anti-mouse CXCL5 (LIX) Antibody, CXCL5, A20098E,BioLegend,662054

CXCL5 is an ELR-CXC chemokine characterized by a Glu-Leu-Arg (ELR) motif preceding the characteristic CXC sequence. CXCL5 chemoattracts and activates neutrophils during inflammation through the binding to CXCR2. CXCL5 exists in different NH2- and COOH-truncated forms, and both NH2-terminal and COOH-terminal truncation result in an increase in neutrophil chemotactic potency.  CXCL5 (8–78) and CXCL5 (9–78) induce a higher neutrophil influxin vivocompared with CXCL5 (1–78). CXCL5 regulates the availability of binding sites for other ELR-CXC chemokines released during inflammation, through its interaction with erythrocyte duffy antigen receptor (DARC). As a result, CXCL5 induces the increase of CXCL1 and CXCL2 in a model of pulmonary inflammation. Therefore, CXCL5 acts as a regulator of chemokine scavenging and pulmonary host defense to bacterial infection. Lung epithelial cells express CXCR2. Consequently, CXCL5 may modulate neutrophil transepithelial and transendothelial migration. Mouse CXCL5 is the ortholog of human CXCL6.