Ultra-LEAF™ Purified anti-mouse IFNgR2 Antibody, IFNgR2, W20010A,BioLegend,671953

IFN-γ initiates and regulates a variety of immune responses. IFNγ receptor is a heterodimer of high affinity IFNγ-binding chain (IFNγR1) and a second accessory protein required for signal transduction known as IFNγR2 (IFN-γ R β chain). IFNγR1 and IFNγR2 belongs to a member of the type II cytokine receptor family. IFNγR1 is constitutively expressed on the surface of T cells, B cells, NK cells, myeloid cells, fibroblasts, endothelial and epithelial cells at the moderate level. IFNγR2 is has low levels of cell surface and high levels of cytoplasmic expression. Though the recycling of IFNγR2 between cell surface and cytoplasm is IFN-γ-independent, it depends on a dipeptide motif on its intracellular domain and its expression is tightly regulated by external stimuli. IFN-γ can decrease mRNA expression of IFNγR2, and modulates T cell responsiveness to IFN-γ. Binding of IFN-γ induces receptor-ligand dimerization, tyrosine phosphorylation of IFNγR1 and internalization. IFNγR2 is resposible for signal transduction, involving Jak1/ Jak2 protein kinases and STAT1 activation. T cells isolated from IFNγR2 deficient mice, or from transgenic mouse (over-expressing IFNγR2) demonstrate impaired capacity to differentiate into the Th1 cells.  Medndelian susceptibility to mycobacterial disease (MSDS) syndrome in human  has been linked to a autosomal recessive and autosomal dominant deficiency of IFNγR2.