Ultra-LEAF Purified anti-mouse/human CD282 (TLR2) Recombinant Antibody - anti-CD282 (TLR2) - QA16A01,BioLegend,153001

Blocking of IL-6 and TNF-a production induced by P3CSK4on RAW264.7 cells was observed during development.

Host

Mouse

Reactivity

Mouse, Human

Application

FC -Quality testedBlock -Verified

Platform ID

BAB812012100

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Product Specifications
Scientific Background

Specifications

NameUltra-LEAF Purified anti-mouse/human CD282 (TLR2) Recombinant Antibody - anti-CD282 (TLR2) - QA16A01
Cat. No.153001
HostMouse
RRIDAB_2650855 (BioLegend Cat. No. 153001)AB_2650856 (BioLegend Cat. No. 153002)
IsotypeMouse IgG1, κ
ReactivityMouse, Human
ApplicationFC -Quality testedBlock -Verified
ClonalityRecombinant
Clone NumberQA16A01
ConcentrationThe antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.
TargetCD282
ImmunogenRecombinant extracellular domain of murine TLR2
PurityThe Ultra-LEAF™ (Low Endotoxin, Azide-Free) Recombinant antibody was purified by affinity chromatography.
Formulation0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
Regulatory StatusResearch Use Only

Scientific Background

CD282 (Toll-like receptor 2, TLR2) is an 85kDa, type I transmembrane protein, with 14 leucine-rich repeats (LRR) in the extracellular domain and a toll/IL-1R (TIR) in the cytoplasmic region. TLR2 is expressed by monocytes/macrophages, dendritic cells, granulocytes, endothelial cell and epithelial cells. TLR2 associates with TLR1 and TLR6 in the cell surface and is involved in the recognition of pathogen-associated molecular patterns (PAMPs) such as peptidoglycan, lipoteihoic acid (LTA), lipoarabinomanan, lipoproteins, and LPS from certain Gram-negative bacteria, yeast, spirochete and fungi.

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