VAV1 (phospho Tyr174) antibody,Genetex,GTX132786

Host

Rabbit

Reactivity

Human

Application

WB

Conjugate

Unconjugated

Platform ID

BAB095088802

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameVAV1 (phospho Tyr174) antibody
Cat. No.GTX132786
Gene ID (Entrez)7409
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB
ClonalityPolyclonal
Concentration0.23 mg/ml (Please refer to the vial label for the specific concentration.)
TargetVAV1
ImmunogenCarrier-protein conjugated synthetic peptide surrounding phospho Tyr174 of human VAV1. The exact sequence is proprietary.
PurityPurified by antigen-affinity chromatography.
Appearance/FormLiquid
FormulationPBS, 1% BSA, 20% Glycerol,0.025% ProClin 300
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]

Synonyms

vav guanine nucleotide exchange factor 1 , VAV

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