VE-Cadherin (E6N7A) Rabbit Monoclonal Antibody (Alexa Fluor^®488 Conjugate)#52393,Cell Signaling Technology (CST),52393

Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development (1). The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1,2). While β- and γ-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking (1-4). Investigators consider E-cadherin an active suppressor of invasion and growth of many epithelial cancers (1-3). Research studies indicate that cancer cells have upregulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch." N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion (3). Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis (5,6). Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers (7,8).Wheelock, M.J. and Johnson, K.R. (2003)Annu Rev Cell Dev Biol19, 207-35.Christofori, G. (2003)EMBO J22, 2318-23.Hazan, R.B. et al. (2004)Ann N Y Acad Sci1014, 155-63.Bryant, D.M. and Stow, J.L. (2004)Trends Cell Biol14, 427-34.Rabascio, C. et al. (2004)Cancer Res64, 4373-7.Yamaoka-Tojo, M. et al. (2006)Arterioscler Thromb Vasc Biol26, 1991-7.Patel, I.S. et al. (2003)Int J Cancer106, 172-7.Sanders, D.S. et al. (2000)J Pathol190, 526-30.Alternate Names7B4; 7B4 antigen; CADH5; cadherin 5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; CDH5; endothelial-specific cadherin; FLJ17376; Vascular endothelial cadherin; VE-cadherin

7B4; 7B4 antigen; CADH5; cadherin 5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; CDH5; endothelial-specific cadherin; FLJ17376; Vascular endothelial cadherin; VE-cadherin