VGLUT2 (F1T6V) Rabbit Monoclonal Antibody#57848,Cell Signaling Technology (CST),57848

Glutamatergic neurons release glutamate, the most common excitatory neurotransmitter. Their synaptic vesicles are filled with glutamate by vesicular glutamate transporters, VGLUTs (1). VGLUT1, also called solute carrier family 17 member 7 (SLC17A7), was first identified as an inorganic phosphate transporter (2). Despite the absence of homology with neurotransmitter transporters, VGLUT1 was later demonstrated to be a glutamate transporter (1) specific to glutamatergic neurons (3). Closely related to VGLUT1, VGLUT2 and VGLUT3 are also involved in glutamate uptake into synaptic vesicles, but define different neuronal subpopulations (4,5). VGLUT1 and VGLUT2 are the most abundant isoforms. VGLUT1 is expressed in the cortex, hippocampus, and cerebellar cortex, while VGLUT2 is mostly found in the thalamus (6,7). VGLUT3 is expressed in hair cells of the auditory system (8).Bellocchio, E.E. et al. (2000)Science289, 957-60.Ni, B. et al. (1996)J Neurochem66, 2227-38.Takamori, S. et al. (2000)Nature407, 189-94.Fremeau, R.T. et al. (2001)Neuron31, 247-60.Fremeau, R.T. et al. (2002)Proc Natl Acad Sci U S A99, 14488-93.Herzog, E. et al. (2001)J Neurosci21, RC181.Kaneko, T. and Fujiyama, F. (2002)Neurosci Res42, 243-50.Seal, R.P. et al. (2008)Neuron57, 263-75.Alternate NamesDifferentiation-associated BNPI; differentiation-associated Na-dependent inorganic phosphate cotransporter; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; DNPI; SLC17A6; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; solute carrier family 17 (vesicular glutamate transporter), member 6; Solute carrier family 17 member 6; Vesicular glutamate transporter 2; VGLU2; VGLUT2

Differentiation-associated BNPI; differentiation-associated Na-dependent inorganic phosphate cotransporter; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; DNPI; SLC17A6; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; solute carrier family 17 (vesicular glutamate transporter), member 6; Solute carrier family 17 member 6; Vesicular glutamate transporter 2; VGLU2; VGLUT2