VRK1 antibody [5D1],Genetex,GTX00703

Host

Mouse

Reactivity

Human

Application

WB ICC/IF IP ELISA IHC

Conjugate

Unconjugated

Platform ID

BAB089002989

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameVRK1 antibody [5D1]
Cat. No.GTX00703
Gene ID (Entrez)7443
HostMouse
IsotypeIgG1
ReactivityHuman
ConjugationUnconjugated
ApplicationWB ICC/IF IP ELISA IHC
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetVRK1
ImmunogenSynthetic peptide corresponding to N-terminus of human VRK1, MPRVKAAQAGRQSSAKRHL-C
PurityPurified IgGFrom tissue culture supernatant
Appearance/FormLiquid
FormulationFilter-sterilized PBS, 50% Glycerol,No preservatives
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

Synonyms

VRK serine/threonine kinase 1 , PCH1 , PCH1A

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