Villin-1, Human, mAb 9H11,Hycult Biotech,HM2442

The Villin-1 monoclonal antibody, HM2442 clone 9H11, targets human villin-1, a cytoskeletal protein of 92.5 kDa found in the microvilli of intestinal epithelium enterocytes and kidney proximal tubular cells. As a critical component of cellular architecture, it is indicative of cellular restructuring or damage. Its presence in bodily fluids like blood and urine reflects these changes. The detection of villin-1 in patients with acute kidney injury (AKI) highlights its potential as a biomarker for renal health. Notably, villin-1 levels respond to treatments like necrostatin-1 during ischemia-reperfusion events. Beyond renal implications, villin-1’s expression profiles contribute to prognostic evaluations in diseases such as hepatocellular carcinoma. This enhances its profile as a multifaceted marker. Its role extends to gastroenterology, where it acts as a mucosal integrity indicator. This is crucial for diagnosing ischemic intestinal damage commonly associated with necrotizing enterocolitis. The HM2442 clone 9H11 is adapted for a variety of laboratory techniques, including immunohistochemistry (IHC), enzyme-linked immunosorbent assays (ELISA) , and Western blot applications. It makes it an invaluable tool for researchers exploring villin-1’s role in health and disease.