Vinculin antibody [N3C1], Internal,Genetex,GTX109749

Host

Rabbit

Reactivity

Human, Mouse, Rat, Pig

Application

WB IHC-P

Conjugate

Unconjugated

Platform ID

BAB186767304

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameVinculin antibody [N3C1], Internal
Cat. No.GTX109749
Gene ID (Entrez)7414
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat, Pig
ConjugationUnconjugated
ApplicationWB IHC-P
ClonalityPolyclonal
Concentration0.11 mg/ml (Please refer to the vial label for the specific concentration.)
TargetVCL
ImmunogenRecombinant protein encompassing a sequence within the center region of human Vinculin. The exact sequence is proprietary.
PurityPurified by antigen-affinity chromatography.
Appearance/FormLiquid
FormulationPBS, 1% BSA, 20% Glycerol,0.025% ProClin 300
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq]

Synonyms

vinculin , CMD1W , CMH15 , HEL114 , MV , MVCL

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