Vitronectin (F7A8D) Rabbit Monoclonal Antibody#82821,Cell Signaling Technology (CST),82821

Vitronectin (VTN) is a multidomain adhesive glycoprotein synthesized mostly in the liver and secreted to blood plasma and extracellular matrix (ECM) (1,2). The protein has an N-terminal SMB fragment mediating binding to PAI-1 and UPAR, followed by an RGD region mediating its interaction with integrins, and C-terminal hemopexin-like domains mediating its interaction with various ECM components such as collagens, tenascins, and plasminogen (2,3). VTN has been implicated as a regulator of many diverse physiological processes, including coagulation, complement-dependent immune response, cell attachment and spreading, angiogenesis, hemostasis, and vascular remodeling (4-6). Increased VTN expression promotes cancer cell migration, adhesion, and metastasis in neuroblastoma, ovarian cancer, and breast cancer cells (7-9).Schvartz, I. et al. (1999)Int J Biochem Cell Biol31, 539-44.Felding-Habermann, B. and Cheresh, D.A. (1993)Curr Opin Cell Biol5, 864-8.Pellegrini, A. and Pietrocola, G. (2024)Microorganisms12, 1385. doi: 10.3390/microorganisms12071385.Leavesley, D.I. et al. (2013)IUBMB Life65, 807-18.Li, R. et al. (2014)J Vasc Res51, 110-7.Preissner, K.T. and Seiffert, D. (1998)Thromb Res89, 1-21.Burgos-Panadero, R. et al. (2019)BMC Cancer19, 479.Yoshimura, A. et al. (2018)BMC Cancer18, 1065.Bera, A. et al. (2020)PLoS One15, e0242141.Alternate Namescomplement S-protein; epibolin; S-protein; serum spreading factor; Serum-spreading factor; somatomedin B; Somatomedin-B; V75; Vitronectin; vitronectin (serum spreading factor, somatomedin B, complement S-protein); Vitronectin V10 subunit; Vitronectin V65 subunit; VN; VNT; VTN; VTNC

complement S-protein; epibolin; S-protein; serum spreading factor; Serum-spreading factor; somatomedin B; Somatomedin-B; V75; Vitronectin; vitronectin (serum spreading factor, somatomedin B, complement S-protein); Vitronectin V10 subunit; Vitronectin V65 subunit; VN; VNT; VTN; VTNC