Whitlow/218 Linker (E3U7Q) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate)#69310,Cell Signaling Technology (CST),69310

Whitlow/218 Linker (E3U7Q) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate) recognizes exogenously expressed levels of scFv-based CARs containing a Whitlow/218 linker.

Host

Rabbit

Reactivity

All Species Expected

Application

Flow Cytometry (Live): 1:50

Platform ID

BAB082904538

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameWhitlow/218 Linker (E3U7Q) Rabbit Monoclonal Antibody (Alexa Fluor®647 Conjugate)#69310
Cat. No.69310
HostRabbit
SensitivityTransfected Only
ReactivityAll Species Expected
ApplicationFlow Cytometry (Live): 1:50
ImmunogenIgG
FormulationSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

The Whitlow/218 peptide is a commonly used linker that connects the variable heavy (VH) domain and variable light (VL) domain of single-chain variable fragments (scFvs) and chimeric antigen receptors (CARs) that utilize an extracellular domain scFv for target antigen recognition. The Whitlow/218 linker affords the scFv with enhanced resistance to proteolysis and aggregation (1).Whitlow, M. et al. (1993)Protein Eng6, 989-95.

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