Xanthine Oxidase antibody (HRP),Genetex,GTX40541

Host

Rabbit

Reactivity

Bovine

Application

WB IP Dot ELISA

Conjugate

Horseradish peroxidase(HRP)

Platform ID

BAB712693589

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameXanthine Oxidase antibody (HRP)
Cat. No.GTX40541
Gene ID (Entrez)280960
HostRabbit
IsotypeIgG
ReactivityBovine
ConjugationHorseradish peroxidase(HRP)
ApplicationWB IP Dot ELISA
ClonalityPolyclonal
Concentration10 mg/ml (Please refer to the vial label for the specific concentration.)
TargetXDH
ImmunogenFull-length Xanthine Oxidase from bovine buttermilk
PurityIgG fractionThis product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above.
Appearance/FormLiquid
Formulation20mM Potassium Phosphate, 150mM NaCl, 1% BSA,0.01% Gentamicin Sulfate
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

In normal tissues this enzyme exists predominantly as Xanthine Dehydrogenase which converts hypoxanthine and xanthine to uric acid, a critical plasma antioxidant. During ischemia, Xanthine Dehydrogenase is reversibly converted to the oxygen radical-producing Xanthine Oxidase by oxidation of essential sulfhydryl groups, or irreversibly, through limited proteolytic cleavage of the amino-terminus. Aldehyde Oxidase has a higher affinity for aldehydes than purines, but produces O2- in a manner very similar to Xanthine Oxidase because both oxidases possess nearly identical internal electron transport systems.

Synonyms

xanthine dehydrogenase , XOR

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