YTHDF2 antibody [HL1354],Genetex,GTX636774

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB ICC/IF IHC-P

Conjugate

Unconjugated

Platform ID

BAB648102079

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameYTHDF2 antibody [HL1354]
Cat. No.GTX636774
Gene ID (Entrez)51441
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetYTHDF2
ImmunogenCarrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human YTHDF2. The exact sequence is proprietary.
PurityAffinity purified by Protein A.
Appearance/FormLiquid
FormulationPBS,No preservatives
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

Synonyms

YTH N6-methyladenosine RNA binding protein 2 , CAHL , HGRG8 , NY-REN-2

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