Zebrafish DIO3 Antibody / Iodothyronine Deiodinase 3 Antibody (RZ1417),NSJ Bioreagent,RZ1417

Host

Rabbit

Reactivity

Zebrafish

Platform ID

BAB763408773

Suppliers

(44)

MoreBio Inc.

+82-2-406-2942

Country:South Korea
City:Hanam-si
Morebio Inc., 25 Misa Riverbyeon-seo, Hanam-si, Gyeonggi-do, Testa Tower F810 (12918)

Biomax Scientific Sdn Bhd

+60-33-122-7461

Country:Malaysia
12, Jalan Temenggong Taman Desawira, 42500 Telok P. Garang Selangor, Malaysia

Interlab Co. Ltd

+886-22-736-7100

Country:Taiwan, China
4th floor, No. 149-17, Section 2, Keelung Road, Taipei,China- Taiwan 110

NSJ Bioreagent

Headquarters

9921 Carmel Mountain Rd 352 San Diego CA 92129

Contact

Tel: 858.663.9055
Fax:

Product Specifications
Scientific Background

Specifications

NameZebrafish DIO3 Antibody / Iodothyronine Deiodinase 3 Antibody (RZ1417)
Cat. No.RZ1417
Accession NumberA0A8M1P485
HostRabbit
IsotypeRabbit Ig
ReactivityZebrafish
Working DilutionsImmunohistochemistry (FFPE) : 2-5ug/ml
ClonalityPolyclonal (rabbit origin)
Formulation0.5mg/ml if reconstituted with 0.2ml sterile DI water
StorageAfter reconstitution, the Zebrafish DIO3A Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Scientific Background

Zebrafish DIO3 Antibody / Iodothyronine Deiodinase 3 Antibody recognizes DIO3A, a member of the iodothyronine deiodinase family that regulates thyroid hormone activity through enzymatic inactivation of thyroxine (T4) and triiodothyronine (T3). DIO3 functions as the principal thyroid hormone-inactivating deiodinase and plays a critical role in maintaining appropriate hormone concentrations during embryonic development, tissue differentiation, and physiological homeostasis. Through its ability to control local thyroid hormone availability, DIO3 serves as an important regulator of growth, metabolism, and developmental timing.Zebrafish DIO3 Antibody is widely used for studying endocrine signaling and vertebrate development. Thyroid hormones influence numerous biological processes, including nervous system maturation, organogenesis, skeletal development, metabolism, and cellular differentiation. DIO3 helps establish tissue-specific thyroid hormone gradients by limiting hormone activity in developing tissues and preventing excessive thyroid hormone signaling. As a result, DIO3 expression is frequently examined in studies investigating developmental regulation and endocrine control mechanisms.Zebrafish DIO3 Antibody is also valuable for research involving neurodevelopment and tissue maturation. Precise regulation of thyroid hormone signaling is essential for normal brain development and neuronal differentiation. By controlling local concentrations of active thyroid hormones, DIO3 contributes to the coordination of developmental programs that influence cell proliferation, migration, and specialization. Expression analysis of DIO3 can therefore provide important insights into the molecular pathways that regulate vertebrate nervous system development and function.Zebrafish DIO3 Antibody supports research involving thyroid hormone metabolism, endocrine biology, developmental signaling, and metabolic regulation. Because zebrafish embryos provide a powerful model for studying hormone-dependent developmental processes in vivo, DIO3 serves as an important marker for investigations of thyroid hormone homeostasis and tissue-specific regulation of endocrine pathways.Zebrafish DIO3 Antibody is additionally relevant for studies of growth regulation, metabolic adaptation, and disease-associated alterations in thyroid hormone signaling. As the major thyroid hormone-inactivating enzyme, DIO3 remains an important target for understanding how endocrine signals coordinate vertebrate development, physiology, and cellular homeostasis.Researchers studying thyroid hormone metabolism, endocrine regulation, and tissue-specific control of thyroid hormone signaling may also be interested in ourDIO3 Antibody / Thyroid Hormone Metabolism Enzyme Antibody.This Zebrafish antibody is part of a broaderZebrafish / Danio rerio antibody paneloffered by NSJ Bioreagents.

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