Zebrafish Lysozyme Antibody / Lyz (RZ1236),NSJ Bioreagent,RZ1236

The Zebrafish Lysozyme antibody targets Lyz, a key innate immune enzyme essential for antibacterial defense, phagocyte function, and early host-protection mechanisms in Danio rerio. Zebrafish, also known as Danio rerio, express lyz as one of the most abundant antimicrobial effector genes in macrophages and neutrophils. Lysozyme is a secreted or granule-stored enzyme that hydrolyzes peptidoglycan bonds in bacterial cell walls, contributing to bacterial lysis and shaping innate immune responses during infection, inflammation, and tissue injury. In developing zebrafish, Lyz expression highlights myeloid lineage emergence and provides a sensitive readout of innate immune maturation.Lyz belongs to the c-type lysozyme family, a conserved group of small enzymatic proteins involved in first-line host defense. In zebrafish embryos, lyz expression initiates early in primitive myeloid progenitors located in the rostral blood island and later expands to definitive myeloid cells in the kidney marrow analog. A Zebrafish Lysozyme antibody is suitable for research applications examining cytoplasmic and granule-associated expression in macrophages, neutrophils, and other innate immune cells during development or immune challenge.Functionally, Lyz contributes to multiple innate immune processes beyond direct bacterial killing. It modulates inflammatory signaling, shapes microbiome interactions, and participates in phagosomal maturation within macrophages. In zebrafish larvae, lyz-expressing neutrophils are rapidly recruited to sites of infection or wounding, where they release lysozyme-rich granules as part of the antimicrobial response. Lyz expression is frequently used as a hallmark marker for tracking neutrophil behavior, monitoring immune activation, and studying inflammatory disease models. Because zebrafish are transparent during early development, Lyz provides a powerful marker for real-time visualization of innate immunity.Structurally, zebrafish Lyz contains the canonical catalytic residues and alpha-helical domains characteristic of c-type lysozymes. These features enable hydrolysis of bacterial peptidoglycan and support interactions within phagosomes and inflammatory microenvironments. Zebrafish lyz maps to chromosome 12, with regulatory elements activated by inflammatory stimuli and transcription factors such as pu.1/spi1b that specify myeloid lineage identity. Co-localization studies often detect Lyz alongside macrophage and neutrophil markers such as mpx, mpeg1.1, and lcp1, reflecting its core role in innate immune cell function.A Zebrafish Lysozyme antibody is suitable for detecting Lyz in studies of innate immunity, inflammation, host-pathogen interactions, and myeloid lineage development in Danio rerio. Its strong association with neutrophils and macrophages allows researchers to map immune cell distribution, characterize inflammatory responses, and evaluate genetic or environmental factors affecting myelopoiesis. Lyz expression is also valuable in toxicology and infection models, where it provides insight into immune competence and antimicrobial defense. These features make the antibody a key tool for research in vertebrate immunology, developmental myeloid biology, and inflammation signaling, and it is supplied for research use by NSJ Bioreagents.This Zebrafish antibody is part of abroader Zebrafish / Danio rerio antibody paneloffered by NSJ Bioreagents.