Zebrafish STAT5A Antibody / Signal Transducer And Activator Of Transcription 5 Antibody (RZ1451),NSJ Bioreagent,RZ1451

Zebrafish STAT5A Antibody / Signal Transducer And Activator Of Transcription 5 Antibody recognizes STAT5A, a member of the STAT family of latent cytoplasmic transcription factors that mediates cellular responses to cytokines, growth factors, and hormones. STAT5A is activated through phosphorylation by Janus kinases following stimulation of receptors for prolactin, growth hormone, interleukins, and other signaling molecules. Upon activation, STAT5A dimerizes and translocates to the nucleus, where it regulates the expression of genes involved in cell proliferation, differentiation, survival, and immune function.In zebrafish, STAT5A contributes to hematopoiesis, immune responses, and developmental processes controlled by cytokine signaling pathways. Activation of the JAK STAT pathway regulates numerous biological functions including growth, metabolism, and tissue homeostasis. Because STAT signaling mechanisms are highly conserved among vertebrates, zebrafish provide an effective model for studying cytokine mediated gene regulation and developmental biology. Alterations in STAT5A activity have been associated with abnormal cell growth and impaired immune responses in mammalian systems.STAT5A functions downstream of multiple cytokine receptors and participates in signaling networks that influence stem cell maintenance, lymphocyte development, and endocrine responses. Aberrant activation of STAT5A has been implicated in leukemia, lymphoma, breast cancer, and other proliferative disorders. Consequently, STAT5A has emerged as an important target for studies of signal transduction, hematopoiesis, and oncogenic pathways.Zebrafish STAT5A Antibody / Signal Transducer And Activator Of Transcription 5 Antibody is useful for investigations of JAK STAT signaling, developmental biology, immune regulation, and hematopoiesis. The evolutionary conservation of STAT5A makes zebrafish an excellent model for understanding cytokine dependent signaling pathways and mechanisms involved in growth, differentiation, and disease.This Zebrafish antibody is part of a broaderZebrafish / Danio rerio antibody paneloffered by NSJ Bioreagents.