alpha 1 Antitrypsin antibody [11G2],Genetex,GTX83663

Host

Mouse

Reactivity

Human, Dog, Monkey

Application

WB IHC-P IP

Conjugate

Unconjugated

Platform ID

BAB256411330

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Namealpha 1 Antitrypsin antibody [11G2]
Cat. No.GTX83663
Gene ID (Entrez)5265
HostMouse
IsotypeIgG1
ReactivityHuman, Dog, Monkey
ConjugationUnconjugated
ApplicationWB IHC-P IP
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetSERPINA1
ImmunogenFull-length protein expressed in 293T cell transfected with human SERPINA1 expression vector
PurityPurified by affinity chromatographyFrom tissue culture supernatant
Appearance/FormLiquid
FormulationPBS, 1% BSA, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT (SPAAT) is a reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

Synonyms

serpin family A member 1 , A1A , A1AT , AAT , PI , PI1 , PRO2275 , alpha1AT , nNIF

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