alpha 2 Macroglobulin antibody,Genetex,GTX54918

Host

Rabbit

Reactivity

Human, Rat

Application

WB

Conjugate

Unconjugated

Platform ID

BAB132159735

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Namealpha 2 Macroglobulin antibody
Cat. No.GTX54918
Gene ID (Entrez)2
HostRabbit
IsotypeIgG
ReactivityHuman, Rat
ConjugationUnconjugated
ApplicationWB
ClonalityPolyclonal
ConcentrationBatch dependent (Please refer to the vial label for the specific concentration.)
TargetA2M
ImmunogenKLH-conjugated synthetic peptide encompassing a sequence within the center region of alpha 2 Macroglobulin. The exact sequence is proprietary.
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
Formulation0.42% Potassium Phosphate, 0.87% NaCl, 30% Glycerol,0.01% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Synonyms

alpha-2-macroglobulin , A2MD , CPAMD5 , FWP007 , S863-7

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