anti-human BMP-3 monoclonal antibody Anti-Human 100 µg,Reliatech,101-M234

BMP3, also known as osteogenin, the most abundant BMP in adult bone, is one of at least 15 structurally and functionally related BMPs, which are members of the TGFβ superfamily (13). BMPs were originally identified as protein regulators of cartilage and bone formation. They have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs also regulate the growth, differentiation, chemotaxis, and apoptosis of various cell types. Similar to most other TGFβfamily proteins, BMPs are highly conserved across animal species. At the amino acid sequence level, mature human and rat BMP3 are 98% identical. BMP3 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. Biologically active BMP3 is a disulfidelinked homodimer of the carboxyterminal 110 amino acid residues that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond (4). The role of BMP3 in bone is contradictory since, unlike osteogenin purified from bone, recombinant BMP3 has not shown osteogenic function (5). Several studies indicate that BMP3 is an inhibitor of osteogenic BMPs. BMP3 dorsalizes Xenopus embryos, the opposite effect of BMP2 or 4, which cause ventralization. BMP3 inhibits alkaline phosphatase production and induction of osteoblastic target genes in undifferentiated mesenchymal and osteogenic cell lines that have been treated with BMP2. BMP3 also induces the expression of TGFβ/ activin responsive genes, but not BMPresponsive genes.

BMP3; BMP-3A