anti-human CLN-2 monoclonal antibody Anti-Human 50 µg,Reliatech,101-M327

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human CLN-2 recombinant protein (also called Tripeptidyl-peptidase I)

Host

Mouse

Reactivity

Human

Application

WB

Platform ID

BAB059228552

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-human CLN-2 monoclonal antibody Anti-Human 50 µg
Cat. No.101-M327
Accession NumberO14773
HostMouse
IsotypeIgG2
ReactivityHuman
ApplicationWB
Clone Number(#9V1)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

Tripeptidyl-peptidase I (TPP1), also known as CLN2, is a lysosomal serine protease detected in all tissues examined, with highest levels shown in heart and placenta. It is an aminopeptidase that cleaves tripeptides from the free N-terminus of polypeptides and may also have endopeptidase activity. Defects in TPP1 are the cause of classical late-infantile neuronal ceroid lipofusionosis, also known as ceroid lipofusionosis neuronal 2 (CLN2), a fatal childhood neurodegenerative disease characterized by progressive visual and mental decline, motor disturbance, epilepsy, and behavioral changes.

Synonyms

TPP1; CLN2; GIG1; LPIC; TPP-1

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