anti-human E-Cadherin monoclonal antibody Anti-Human 100 µg,Reliatech,101-M594

Epithelial (E)Cadherin (E-CAD), also known as Cadherin1, cell-CAM120/ 80 in the human, uvomorulin in the mouse, Arc1 in the dog, and LCAM in the chicken, is a member of the Cadherin family of cell adhesion molecules (gene name CDH1). Cadherins are calcium-dependent transmembrane proteins which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, α, β, and γ (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. E-Cadherin may also play a role in tumor development, as loss of E-Cadherin has been associated with tumor invasiveness. E-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a singlepass-transmembrane domain, and a short carboxyterminal cytoplasmic domain responsible for interacting with the catenins. E-Cadherin contains five extracellular calciumbinding domains of approx. 110 amino acids each (amino acids 155-697).

CDH1; UVO; CDHE; ECAD; LCAM; Arc-1; CD324