anti-human MCAM monoclonal antibody Anti-Human 50 µg,Reliatech,101-M563

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with extracellular domain of human recombinant protein of MCAM (also called CD146).

Host

Mouse

Reactivity

Human

Application

WB, FC

Platform ID

BAB374733359

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-human MCAM monoclonal antibody Anti-Human 50 µg
Cat. No.101-M563
Accession NumberP43121
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationWB, FC
Clone Number(#4H55)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

Melanoma Cell Adhesion Molecule (MCAM)/CD146 is a surface antigen on metastatic human melanoma cells originally called MUC18 or A32. The 113 kDa glycoprotein is a member of the immunoglobulin superfamily that shows significant homology to several cell adhesion molecules, notably N-CAM. MCAM/CD146 is also identical to the endothelial cell antigen S-Endo. In addition to melanoma and endothelial cells, MCAM/CD146 is expressed on smooth muscle cells, cerebellar cortex, trophoblasts and activated T cells. MCAM/CD146 is also expressed on a variety of malignant cell types including: vascular and smooth muscle tumors gliomas and neuroblastomas, prostate tumors, and in tumors arising from hematologic malignancies. As a proposed adhesion receptor, MCAM/CD146 may have an important role during tumor invasion and metastasis.

Synonyms

MCAM; CD146; MUC18

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