anti-human MCP-4 monoclonal antibody Anti-Human 500 µg,Reliatech,101-M76

Produced in BALB/c mice using recombinant human MCP-4 as the immunizing antigen. This IgG1, antibody was purified from a Protein A chromatography column.

Host

Mouse

Reactivity

Human

Application

ELISA, WB, N

Platform ID

BAB624758347

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-human MCP-4 monoclonal antibody Anti-Human 500 µg
Cat. No.101-M76
Accession NumberQ99616
HostMouse
IsotypeIgG1, kappa
ReactivityHuman
ApplicationELISA, WB, N
Appearance/Formlyophilized from PBS
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
StorageThe lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Regulatory StatusFor research use only

Scientific Background

Monocyte Chemoattractant Protein-4 (MCP-4), is a CC chemokine that acts as a chemoattractant for monocytes, eosinophils and T cells and as an activator of basophils. Human MCP-4/CCL13 cDNA encodes a 98 amino acid residue precursor protein with a 23 amino acid residue hydrophobic signal peptide that is cleaved to yield an 8 kDa, 75 aa mature CCL13. Mature MCP-4 lacks any potential N-glycosylation sites and shares a pyroglutamate proline motif with other human MCP proteins. Human MCP-4 is most homologous to MCP-1, -3 and Eotaxin, exhibiting approximately 65-66% amino acid sequence identity. CCL13 or MCP-4 mRNA is expressed by a number of activated cell types, including endothelial cells, macrophages, bronchial epithelium and type II alveolar cells, and perhaps lymphocytes. The bioactivities of MCP-4 are mediated by the CC chemokine receptors CCR2 and CCR3.

Synonyms

CCL13; NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13

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