anti-human ST2 EC monoclonal antibody Anti-Human 50 µg,Reliatech,101-M642

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with the extracellular domain of recombinant human ST2, also called IL-R4.

Host

Mouse

Reactivity

Human

Application

WB, N

Platform ID

BAB188389054

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-human ST2 EC monoclonal antibody Anti-Human 50 µg
Cat. No.101-M642
Accession NumberQ01638
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationWB, N
Working DilutionsWB: 1:500-1000
Clone Number(#6B72)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

The Interleukin 1 receptor family comprises at least nine members. All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor) signaling domain that is also conserved in the Toll-like receptor family. A subtype of the IL-1 R family, SIGIRR (single Ig domain-containing IL-1 R-related molecule) differs from the other nine members by having only one Ig domain.ST2L, also known as IL-1 R4, is a transmembrane glycoprotein in the interleukin-1 receptor family. ST2L is expressed on mast cells and Th2 cells as well as on stressed cardiac myocytes and airway epithelia. ST2L associates with IL-1R AcP to form a receptor complex for IL-33. Alternative splicing generates ST2, a secreted isoform that functions as an inhibitor of IL-33 signaling. Within the ECD, mouse ST2L shares 68% aa sequence identity with human ST2L.

Synonyms

IL1RL1; T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R

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