anti-human TIMP-1 monoclonal antibody Anti-Human 50 µg,Reliatech,101-M123

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1). The IgG fraction of the tissue culture supernatant was purified by

Host

Mouse

Reactivity

Human

Application

WB, IHC (P)

Platform ID

BAB563576464

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-human TIMP-1 monoclonal antibody Anti-Human 50 µg
Cat. No.101-M123
Accession NumberP01033
HostMouse
IsotypeIgG2
ReactivityHuman
ApplicationWB, IHC (P)
Clone Number(#4A16)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

Synonyms

TIMP1; EPA; EPO; HCI; CLGI; TIMP

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.