anti-human TNFSF1A (TNF-alpha) monoclonal antibody Anti-Human 50 µg,Reliatech,101-M846

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human TNFSF1A recombinant protein (also called TNF-a)

Host

Mouse

Reactivity

Human

Application

N

Platform ID

BAB251370073

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-human TNFSF1A (TNF-alpha) monoclonal antibody Anti-Human 50 µg
Cat. No.101-M846
Accession NumberP01374
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationN
Clone Number(#3F67)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. Human TNF-α consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.

Synonyms

TNFSF1A

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