anti-human TNFSF5 (CD40 ligand) monoclonal antibody Anti-Human 50 µg,Reliatech,101-M682

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of TNFSF5 extracellular domain.

Host

Mouse

Reactivity

Human

Application

WB, IHC (P)

Platform ID

BAB438913802

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-human TNFSF5 (CD40 ligand) monoclonal antibody Anti-Human 50 µg
Cat. No.101-M682
Accession NumberP29965
HostMouse
IsotypeIgG2
ReactivityHuman
ApplicationWB, IHC (P)
Clone Number(#14B9)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

CD40 ligand (CD40L), also known as CD154, TNFSF5, TRAP or gp39, is a 260 amino acid type II transmembrane glycoprotein belonging to the TNF family. Murine CD40L consists of a 22 aa cytoplasmic domain, a 24 aa transmembrane domain, and 214 aa extracellular domain bearing a single glycosylation site. CD40L is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including NK cells, mast cells, basophils and eosinophils. Murine CD40L shares 78% amino acid sequence identity with human CD40L. Native bioactive soluble CD40L exists. Soluble human trimeric CD40L secreted by stimulated T cells has been shown to be generated by proteolysis in the microsomes. Both membrane bound and soluble CD40L induce similar effects on B cells.

Synonyms

CD40LG; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L

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