anti-mouse CD80 monoclonal antibody Anti-Mouse 100 µg,Reliatech,103-M144

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a Armenian Hamster immunized with recombinant Mouse CD80 protein. IgG fraction of the culture supernatant was purified by Protein G affinity chromatography.

Host

Armenian Hamster

Reactivity

Mouse

Application

IHC, FC

Platform ID

BAB184091118

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-mouse CD80 monoclonal antibody Anti-Mouse 100 µg
Cat. No.103-M144
Accession NumberQ00609
HostArmenian Hamster
IsotypeIgG
ReactivityMouse
ApplicationIHC, FC
Clone Number(#MAB0713)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

B7-1 (CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily.

Synonyms

Cd80; B71; Ly53; TSA1; Cd28l; Ly-53; MIC17

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