anti-mouse Cathepsin B monoclonal antibody Anti-Mouse 100 µg,Reliatech,103-M314

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Cathepsin-B.

Host

Rat

Reactivity

Mouse

Application

WB

Platform ID

BAB995847725

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-mouse Cathepsin B monoclonal antibody Anti-Mouse 100 µg
Cat. No.103-M314
Accession NumberP10605
HostRat
IsotypeIgG1
ReactivityMouse
ApplicationWB
Clone Number(#6C15)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

Cathepsin B (CTSB) is a papain-family cysteine protease that is normally located in lysosomes, and is a member of a superfamily of structurally similar tissue proteinases having a 25 kDa catalytic unit. Cathepsin B is synthesized as a preproenzyme and the primary pathways for its normal trafficking to the lysosome utilize mannose 6-phosphate receptors (MPRs). Mature cathepsin B has the ability to degrade several extracellular matrix components at both neutral and acidic pH and has been implicated in the progression of several human and rodent tumors progression and arthritis. Overexpression and altered trafficking of cathepsin B characterize the malignant phenotype of tumor cells, and thus CTSB is suggested as a tumor marker.

Synonyms

Ctsb; CB

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