anti-mouse Ephrin-A1 monoclonal antibody Anti-Mouse 100 µg,Reliatech,103-M375

EphrinA1, also known as B61, LERK1, and EFL1, is a member of the Ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The A-class ligands have a GPI anchor following the conserved sequence. EphrinA1 binds EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. The extracellular domains of human and mouse EphrinA1 share 85% amino acid identity. Only membranebound or Fc -clustered ligands are capable of activating the receptor in vitro. While soluble monomeric ligands bind the receptor, they do not induce receptor autophosphorylation and activation. In vivo, the ligands and receptors display reciprocal expression. Nearly all receptors and ligands are expressed in developing and adult neural tissue. The Eph/Ephrin families also appear to play a role in angiogenesis.

Efna1; B61; Efl1; Epl1; Eplg1; Lerk1; AI325262