anti-mouse HGF Activator Inhibitor Type 1 (HAI-1) monoclonal antibody Anti-Mouse 100 µg,Reliatech,103-M229

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant protein of HAI-1extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity

Host

Rat

Reactivity

Mouse

Application

WB

Platform ID

BAB810802796

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-mouse HGF Activator Inhibitor Type 1 (HAI-1) monoclonal antibody Anti-Mouse 100 µg
Cat. No.103-M229
Accession NumberQ9R097
HostRat
IsotypeIgG2
ReactivityMouse
ApplicationWB
Clone Number(#3G21)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

Hepatocyte growth factor activator inhibitor1 (HAI1) encoded by the Spint1 gene is a Kunitz-type serine protease inhibitor, identified as a strong inhibitor of HGF activator (HGF-A) and matripas. The membraneanchored HAI1 consists of two Kunitz domains, a LDL-recepto-rlike domain, and a C-terminal transmembrane domain. Two soluble forms are generated by ectodomain shedding, one with a single Kunitz domain and the other with two Kunitz domains. HAI1 is not only an inhibitor but also a specific receptor of active HGFA, acting as a reservoir of this enzyme on the cell surface. The shedding of HAI1 and HGFA/HAI1 complex is enhanced by treatment with phorbol 12myristate, 13acetate or IL1β. The regulated shedding is completely inhibited by a synthetic zinc metalloprotease inhibitor.

Synonyms

Spint1; HAI-1

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