anti-mouse Oncostatin M monoclonal antibody Anti-Mouse 100 µg,Reliatech,103-M446

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Oncostatin-M.

Host

Rat

Reactivity

Mouse

Application

WB

Platform ID

BAB562676896

Reliatech

Headquarters

Lindener Straße 15 38300 Wolfenbüttel Germany

Reliatech

Contact

Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Nameanti-mouse Oncostatin M monoclonal antibody Anti-Mouse 100 µg
Cat. No.103-M446
Accession NumberP53347
HostRat
IsotypeIgG2
ReactivityMouse
ApplicationWB
Clone Number(#7H61)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only

Scientific Background

Oncostatin M (OSM) is a member of the IL-6 family of cytokines that is produced primarily by activated T cells and macrophages. OSM induces fibroblast proliferation, inhibits tumor cell proliferation, and plays a role in immune regulation. Mouse OSM binds to the OSM receptor β (OSMRβ) which forms a heteromeric complex with the common IL-6 family receptor subunit, gp130. In contrast, human OSM binds to two distinct receptor complexes, the OSMRβ/gp130 and LIFRβ/gp130 complexes. The ability of human OSM to bind to two receptors may explain the overlapping and distinct activities of human OSM and LIF. OSM induces the activation the JAK2, STAT3, and ERK1/2 pathways.

Synonyms

OSM

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