anti-mouse TIMP-1 monoclonal antibody Anti-Mouse 50 µg,Reliatech,103-M277
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant TIMP-1. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Host
Rat
Reactivity
Mouse
Application
WB
Platform ID
BAB876082711
Reliatech
Contact
Tel: +49 (0) 5331 - 8586987
Fax: +49 (0) 5331- 8586989
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Product Specifications
Scientific Background
Synonyms
Specifications
Nameanti-mouse TIMP-1 monoclonal antibody Anti-Mouse 50 µg
Cat. No.103-M277
Accession NumberP12032
HostRat
IsotypeIgG2
ReactivityMouse
ApplicationWB
Clone Number(#6A34)
Appearance/Formlyophilized
FormulationPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
StorageLyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Regulatory StatusFor research use only
Scientific Background
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Synonyms
Timp1; Clgi; Timp; TIMP-1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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