beta Amyloid 1-42 Antibody (YA3555)(PBS only),MedChemexpress,HY-P83754A

APP functions as a cell surface receptor on neurons, playing roles in neurite growth, neuronal adhesion, and axonogenesis. Interactions between APP molecules on adjacent cells promote synaptogenesis. It participates in cell mobility and transcription regulation via protein-protein interactions, activating transcription through binding to APBB1-KAT5 while inhibiting Notch signaling via interaction with Numb. It couples to apoptosis pathways (e.g., G(o)- and JIP-mediated) and inhibits G(o) alpha ATPase activity (by similarity). As a kinesin I membrane receptor, it mediates axonal transport of beta-secretase and presenilin 1 (by similarity) and facilitates anterograde cargo transport toward synapses. It contributes to copper homeostasis/oxidative stress by reducing copper ions; copper-metallated APP induces neuronal death directly or via Cu²⁺-mediated LDL oxidation in vitro. By binding extracellular matrix components (e.g., heparin, collagen I/IV), it regulates neurite outgrowth. Splice isoforms containing the BPTI domain exhibit protease inhibitor activity. APP triggers an AGER-dependent pathway involving p38 MAPK activation, leading to amyloid-beta peptide internalization and mitochondrial dysfunction in cortical neurons. It supplies Cu²⁺ ions to GPC1 for NO release and heparan sulfate degradation. Amyloid-beta peptides act as lipophilic metal chelators, reducing Cu²⁺/Fe(3+) to Cu(+)/Fe²⁺ and binding lipoproteins (e.g., apoE/J, HDL) to inhibit metal-catalyzed oxidation. They promote tau aggregation and TPK II-mediated phosphorylation, while interaction with overexpressed HADH2 causes oxidative stress and neurotoxicity. Appicans enhance neural cell adhesion to the extracellular matrix and may regulate neurite outgrowth. Gamma-CTF and caspase-cleaved peptides (e.g., C31) strongly potentiate neuronal apoptosis.

A4 antibody; A4_HUMAN antibody; AAA antibody; ABETA antibody; ABPP antibody; AICD-50 antibody; AICD-57 antibody; AICD-59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Alzheimer disease amyloid protein antibody; Amyloid intracellular domain 50 antibody; Amyloid intracellular domain 57 antibody; Amyloid intracellular domain 59 antibody; APP antibody; APPI antibody; Beta amyloid protein 42 antibody; Beta APP42 antibody; Beta-APP40 antibody; Beta-APP42 antibody; C31 antibody; Cerebral vascular amyloid peptide antibody; CVAP antibody; Gamma-CTF(50) antibody; Gamma-CTF(57) antibody; Gamma-CTF(59) antibody; PN-II antibody; PreA4 antibody; Protease nexin-II antibody; S-APP-alpha antibody; S-APP-beta antibody Aβ;