beta Catenin antibody [ZM13],Genetex,GTX01589

Host

Mouse

Reactivity

Human

Application

IHC-P

Conjugate

Unconjugated

Platform ID

BAB592551285

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Namebeta Catenin antibody [ZM13]
Cat. No.GTX01589
Gene ID (Entrez)1499
HostMouse
IsotypeIgG2b
ReactivityHuman
ConjugationUnconjugated
ApplicationIHC-P
ClonalityMonoclonal
ConcentrationBatch dependent (Please refer to the vial label for the specific concentration.)
TargetCTNNB1
ImmunogenRecombinant full-length human beta-catenin (CTNNB1) protein
PurityPurified IgG
Appearance/FormLiquid
FormulationTris-HCl, 0.2% BSA,0.09% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Synonyms

catenin beta 1 , CTNNB , EVR7 , MRD19 , armadillo

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