c-Abl (phospho Tyr245) antibody,Genetex,GTX133980

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB

Conjugate

Unconjugated

Platform ID

BAB910243777

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Namec-Abl (phospho Tyr245) antibody
Cat. No.GTX133980
Gene ID (Entrez)11350
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB
ClonalityPolyclonal
Concentration1.08 mg/ml (Please refer to the vial label for the specific concentration.)
TargetAbl1
ImmunogenCarrier-protein conjugated synthetic peptide surrounding phospho Tyr245 of mouse c-Abl. The exact sequence is proprietary.
PurityPurified by antigen-affinity chromatography.
Appearance/FormLiquid
FormulationPBS, 1% BSA, 20% Glycerol,0.025% ProClin 300
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Synonyms

c-abl oncogene 1, non-receptor tyrosine kinase , AI325092 , Abl , E430008G22Rik , c-Abl

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