c-Kit Antibody (YA6347),MedChemexpress,HY-P86655

c-Kit is a tyrosine-protein kinase that functions as a cell-surface receptor for the cytokine KITLG/SCF, playing a vital role in regulating cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development/function, and melanogenesis. Upon KITLG/SCF binding, c-Kit activates multiple signaling pathways, phosphorylating PIK3R1, PLCG1, SH2B2/APS, and CBL. It triggers the AKT1 pathway via PIK3R1 phosphorylation (the regulatory subunit of phosphatidylinositol 3-kinase) and transmits signals through GRB2 to activate RAS, RAF1, and MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. c-Kit also promotes STAT family member (STAT1/3/5A/5B) activation and PLCG1-mediated production of diacylglycerol and inositol 1,4,5-trisphosphate. Its signaling is modulated by protein phosphatases and receptor internalization/degradation, while activated c-Kit induces phosphorylation of PTPN6/SHP-1, PTPRU, STAT1/3/5A/5B, PIK3R1, CBL, CRK (Crk-II isoform), LYN, MAPK1/ERK2/ERK1, PLCG1, SRC, and SHC1.

C Kit; CD 117; CD117; CD117 antigen; KIT; KIT_HUMAN; Mast/stem cell growth factor receptor; Mast/stem cell growth factor receptor Kit; p145 c-kit; PBT; Piebald trait protein; Proto oncogene c Kit; Proto oncogene tyrosine protein kinase Kit; Proto-oncogene c-Kit; SCF Receptor; SCFR; soluble KIT variant 1; Stem cell factor receptor; tyrosine protein kinase Kit; Tyrosine-protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.