cGAS (D3O8O) Rabbit Monoclonal Antibody#31659,Cell Signaling Technology (CST),31659

cGAS (D3O8O) Rabbit Monoclonal Antibody recognizes endogenous levels of mouse cGAS protein.

Host

Rabbit

Reactivity

Mouse

Application

Western Blotting: 1:1000 Simple WesternTM: 1:50 - 1:250 Immunoprecipitation: 1:200

Platform ID

BAB907954761

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamecGAS (D3O8O) Rabbit Monoclonal Antibody#31659
Cat. No.31659
Accession NumberQ8C6L5, 214763
Gene ID (Entrez)214763
HostRabbit
SensitivityEndogenous
ReactivityMouse
ApplicationWestern Blotting: 1:1000 Simple WesternTM: 1:50 - 1:250 Immunoprecipitation: 1:200
Molecular Weight62
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Cyclic GMP-AMP synthase (cGAS, MB21D1) is an antiviral enzyme that produces the second messenger cyclic-GMP-AMP (cGAMP) in response to cytoplasmic DNA (1,2). The cGAS protein acts as a cytosolic DNA sensor that binds DNA and produces the cGAMP second messenger from ATP and GTP (1,2). cGAMP binds to and activates STING, a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA (1-4). STING is ubiquitously expressed and found predominantly in the ER (3). Following activation, STING translocates with TBK1 to perinuclear endosomes (5). The TBK1 kinase phosphorylates and activates interferon regulatory factors (IRFs) and NF-κB, which leads to the induction of type I interferon and other immune response genes (3-5).Sun, L. et al. (2013)Science339, 786-91.Wu, J. et al. (2013)Science339, 826-30.Ishikawa, H. and Barber, G.N. (2008)Nature455, 674-8.Zhong, B. et al. (2008)Immunity29, 538-50.Ishikawa, H. et al. (2009)Nature461, 788-92.Alternate Names2'3'-cGAMP synthase; cGAMP synthase; cGAS; Cyclic GMP-AMP synthase; E330016A19Rik; FLJ39829; hypothetical protein LOC214763; m-cGAS; Mab-21 domain containing 1; Mab-21 domain-containing protein 1; Mb21d1; OTTMUSP00000021298; RIKEN cDNA E330016A19 gene

Synonyms

2'3'-cGAMP synthase; cGAMP synthase; cGAS; Cyclic GMP-AMP synthase; E330016A19Rik; FLJ39829; hypothetical protein LOC214763; m-cGAS; Mab-21 domain containing 1; Mab-21 domain-containing protein 1; Mb21d1; OTTMUSP00000021298; RIKEN cDNA E330016A19 gene

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