eIF2α Rabbit mAb,ABclonal,A21221

Reactivity

Human, Mouse, Rat

Application

WB, IF/ICC, IHC-P, ELISA

Conjugate

Unconjugated

Platform ID

BAB658352099

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

Tel:
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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameeIF2α Rabbit mAb
Cat. No.A21221
Accession NumberP05198
Gene ID (Entrez)1965
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, IF/ICC, IHC-P, ELISA
Working DilutionsWB:1:4000 - 1:120000 | IF/ICC:1:200 - 1:1000 | IHC-P:1:500 - 1:2000 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC52379
Molecular Weight36kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).

Synonyms

EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eIF2α

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