eIF2 alpha antibody [2E4],Genetex,GTX66838

Host

Mouse

Reactivity

Human, Mouse, Rat, Monkey

Application

WB ICC/IF

Conjugate

Unconjugated

Platform ID

BAB733972106

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameeIF2 alpha antibody [2E4]
Cat. No.GTX66838
Gene ID (Entrez)1965
HostMouse
IsotypeIgG
ReactivityHuman, Mouse, Rat, Monkey
ConjugationUnconjugated
ApplicationWB ICC/IF
ClonalityMonoclonal
ConcentrationBatch dependent (Please refer to the vial label for the specific concentration.)
TargetEIF2S1
ImmunogenPurified recombinant human eIF2α protein fragments expressed in E.coli.
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
Formulation100mM Tris-Glycine, 150mM NaCl, 50% Glycerol,0.2% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

Synonyms

eukaryotic translation initiation factor 2 subunit alpha , EIF-2 , EIF-2A , EIF-2alpha , EIF2 , EIF2A

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