eIF2 alpha (phospho Ser51) antibody,Genetex,GTX24837

Host

Rabbit

Reactivity

Human, Mouse, Rat, Yeast, Drosophila, Cat, Chicken, Caenorhabditis elegans, Primate

Application

WB ICC/IF IHC (Free Floating)

Conjugate

Unconjugated

Platform ID

BAB240741384

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameeIF2 alpha (phospho Ser51) antibody
Cat. No.GTX24837
Gene ID (Entrez)1965
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat, Yeast, Drosophila, Cat, Chicken, Caenorhabditis elegans, Primate
ConjugationUnconjugated
ApplicationWB ICC/IF IHC (Free Floating)
ClonalityPolyclonal
ConcentrationBatch dependent (Please refer to the vial label for the specific concentration.)
TargetEIF2S1
ImmunogenThe antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human eIF2a that contains serine 52. This region is conserved among many species including rat, pig, cow, fruit fly and yeast.
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
FormulationPBS, 0.1% BSA, 50% Glycerol,0.05% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

Synonyms

eukaryotic translation initiation factor 2 subunit alpha , EIF-2 , EIF-2A , EIF-2alpha , EIF2 , EIF2A

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.